Kilroy Was Here!

(Image caption: If this picture makes you feel uncomfortable, you feel empathic pain. This sensation activates the same brain regions as real pain. © Kai Weinsziehr for MPG)

The anatomy of pain

Grimacing, we flinch when we see someone accidentally hit their thumb with a hammer. But is it really pain we feel? Researchers at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig and other institutions have now proposed a new theory that describes pain as a multi-layered gradual event which consists of specific pain components, such as a burning sensation in the hand, and more general components, such as negative emotions. A comparison of the brain activation patterns during both experiences could clarify which components the empathic response shares with real pain. 

Imagine you’re driving a nail into a wall with a hammer and accidentally bang your finger. You would probably injure finger tissue, feel physical distress, focus all your attention on your injured finger and take care not to repeat the misfortune. All this describes physical and psychological manifestations of “pain” – specifically, so-called nociceptive pain experienced by your body, which is caused by the stimulation of pain receptors.

Now imagine that you see a friend injure him or herself in the same way. You would again literally wince and feel pain, empathetic pain in this case. Although you yourself have not sustained any injury, to some extent you would experience the same symptoms: You would feel anxiety; you may recoil to put distance between yourself and the source of the pain; and you would store information about the context of the experience in order to avoid pain in the future.

Activity in the brain

Previous studies have shown that the same brain structures – namely the anterior insula and the cingulate cortex – are activated, irrespective of whether the pain is personally experienced or empathetic. However, despite this congruence in the underlying activated areas of the brain, the extent to which the two forms of pain really are similar remains a matter of considerable controversy.

To help shed light on the matter, neuroscientists, including Tania Singer, Director at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, have now proposed a new theory: “We need to get away from this either-or question, whether the pain is genuine or not.”

Instead, it should be seen as a complex interaction of multiple elements, which together form the complex experience we call “pain”. The elements include sensory processes, which determine, for example, where the pain stimulus was triggered: in the hand or in the foot? In addition, emotional processes, such as the negative feeling experienced during pain, also come into play. “The decisive point is that the individual processes can also play a role in other experiences, albeit in a different activation pattern,” Singer explains – for example, if someone tickles your hand or foot, or you see images of people suffering on television. Other processes, such as the stimulation of pain receptors, are probably highly specific to pain. The neuroscientists therefore propose comparing the elements of direct and empathetic pain: Which elements are shared and which, by contrast, are specific and unique to the each form of pain?

Areas process general components

A study that was published almost simultaneously by scientists from the Max Planck Institute for Human Cognitive and Brain Sciences and the University of Geneva has provided strong proof of this theory: They were able to demonstrate for the first time that during painful experiences the anterior insula region and the cingulate cortex process both general components, which also occur during other negative experiences such as disgust or indignation, and specific pain information – whether the pain is direct or empathic.

The general components signal that an experience is in fact unpleasant and not joyful. The specific information, in turn, tells us that pain – not disgust or indignation – is involved, and whether the pain is being experienced by you or someone else. “Both the nonspecific and the specific information are processed in parallel in the brain structures responsible for pain. But the activation patterns are different,” says Anita Tusche, also a neuroscientist at the Max Planck Institute in Leipzig and one of the authors of the study.

Thanks to the fact that our brain deals with these components in parallel, we can process various unpleasant experiences in a time-saving and energy-saving manner. At the same time, however, we are able register detailed information quickly, so that we know exactly what kind of unpleasant event has occurred – and whether it affects us directly or vicariously. “The fact that our brain processes pain and other unpleasant events simultaneously for the most part, no matter if they are experienced by us or someone else, is very important for social interactions,” Tusche says, “because it helps to us understand what others are experiencing.”

The Christopher Robin Story Book from When we were very young, Now we are six, Winnie the Pooh, The House at Pooh Corner by AA Milne Illustrated by Ernest H Shepard London Methuen & Co Ltd. First Edition 1929

My friend just sent me this so y'all have to suffer too

A brief text history of Gilgamesh, put together for my students.

Everyday Phenomena: The Maillard Reaction

At first glance, steak, French fries, bread, milk caramel, and soy sauce don’t have very many similarities. However, the preparation of these foods all have one thing in common: browning that occurs via the Maillard (my-YAR) reaction.

The Maillard reaction was first discovered in 1912 by Louis-Camille Maillard, and refers to a long chain of reactions that ultimately leads to browning of food. This chain typically begins with the condensation of an amine (often the amino acid lysine) with a reducing sugar (containing an aldehyde); one example of this Amadori rearrangement is shown above with lysine and glucose.

This Amadori product can react in a variety of different ways, including dehydration and deamination to produce a diverse array of molecules that give browned food a distinctive flavor; a few of these compounds are shown above. At the end of the sequence of reactions that occur during browning is a class of polymeric compounds known as melanoidins, which lend a brown color to the food.

Below about 140°C (280°F), the Maillard reaction does not proceed at an appreciable rate, although alkaline conditions (such as the lye used to make pretzels) can accelerate the process. Without this reaction, many foods we enjoy now wouldn’t be nearly as tasty!

Further Reading: Hodge, J. E., J. Agric. Food Chem. 1953, 1 (15), 928-943 (Full text)

In slow motion, vortex rings can be truly stunning. This video shows two bubble rings underwater as they interact with one another. Upon approach, the two low-pressure vortex cores link up in what’s known as vortex reconnection. Note how the vortex rings split and reconnect in two places – not one. According to Helmholtz’s second theorem a vortex cannot end in a fluid–it must form a closed path (or end at a boundary); that’s why both sides come apart and together this way. After reconnection, waves ripple back and forth along the distorted vortex ring; these are known as Kelvin waves. Some of those perturbations bring two sides of the enlarged vortex ring too close to one another, causing a second vortex reconnection, which pinches off a smaller vortex ring. (Image source: A. Lawrence; submitted by Kam-Yung Soh)

Note: As with many viral images, locating a true source for this video is difficult. So far the closest to an original source I’ve found is the Instagram post linked above. If you know the original source, please let me know so that I can update the credit accordingly. Thanks!

Rishi coffin for a commoner

Second Intermediate Period, Dynasty 17, 1580–1550 B.C. (find spot unknown)

In Dynasty 17 a new type of coffin appeared in Thebes: anthropoid, but no longer conceived solely as an inner coffin, and resting on its back because of a change in funerary customs whereby the deceased was no longer laid on one side. The anthropoid coffin was to become the burial container of choice among royals and commoners alike. The earliest examples are decorated in paint with a feather pattern, and so they are known by the Arabic word for “feathered,” rishi. Carved from local sycamore because the Thebans no longer had access to imported cedar, all rishi coffins, royal or private, show the deceased wearing the royal nemes headdress. This example was clearly a stock item made for a commoner, for a blank space was left for the owner’s name to be inserted at the end of the vertical inscription on the lid (a conventional offering formula for the dead).

Great vulture’s wings envelop the legs and lower abdomen. Even the top of the headdress is decorated with a feather pattern so that the deceased appears as a human-headed bird according to the concept of the ba, or mobile spirit. The ba could travel to any place and transform itself into anything it desired. The face on the coffin is painted black, not to represent the unknown owner’s race but to reinforce his identification with Osiris. The flesh of the god of death and resurrection was often shown as black or green to signify the black silt that fertilized the land with each year’s Nile flood, and the new life in the form of green vegetation that it brought forth. Painted on the chest is a pectoral, or chest ornament, in the form of a vulture and cobra, symbols of Nekhbet and Wadjyt, the tutelary goddesses of Upper and Lower Egypt.

Source: Museum of Fine Arts Boston

Which Shakespeare Play Should I See?

This coming Saturday is the 400th anniversary of Shakespeare’s death! Not sure what Shakespeare play you should see or read to commemorate the occasion? No worries! I’ve put together a little flowchart to help you make up your mind.

HAPPY SHAKESPEARE-ING, EVERYONE!

im putting together a couple of scottish folk mixes bc that’s what i do and im honestly curious if anyone in my country has ever been unequivocally happy about anything ever