Fructose alters hundreds of brain genes, which can lead to a wide range of diseases
A range of diseases — from diabetes to cardiovascular disease, and from Alzheimer’s disease to attention deficit hyperactivity disorder — are linked to changes to genes in the brain. A new study by UCLA life scientists has found that hundreds of those genes can be damaged by fructose, a sugar that’s common in the Western diet, in a way that could lead to those diseases.
However, the researchers discovered good news as well: An omega-3 fatty acid known as docosahexaenoic acid, or DHA, seems to reverse the harmful changes produced by fructose.
“DHA changes not just one or two genes; it seems to push the entire gene pattern back to normal, which is remarkable,” said Xia Yang, a senior author of the study and a UCLA assistant professor of integrative biology and physiology. “And we can see why it has such a powerful effect.”
DHA occurs naturally in the membranes of our brain cells, but not in a large enough quantity to help fight diseases.
“The brain and the body are deficient in the machinery to make DHA; it has to come through our diet,” said Fernando Gomez-Pinilla, a UCLA professor of neurosurgery and of integrative biology and physiology, and co-senior author of the paper.
DHA strengthens synapses in the brain and enhances learning and memory. It is abundant in wild salmon and, to a lesser extent, in other fish and fish oil, as well as walnuts, flaxseed, and fruits and vegetables, said Gomez-Pinilla, who also is a member of UCLA’s Brain Injury Research Center.
Americans get most of their fructose in foods that are sweetened with high-fructose corn syrup, an inexpensive liquid sweetener made from corn starch, and from sweetened drinks, syrups, honey and desserts. The Department of Agriculture estimates that Americans consumed an average of about 27 pounds of high-fructose corn syrup in 2014. Fructose is also found is in most baby food and in fruit, although the fiber in fruit substantially slows the body’s absorption of the sugar — and fruit contains other healthy components that protect the brain and body, Yang said.
To test the effects of fructose and DHA, the researchers trained rats to escape from a maze, and then randomly divided the animals into three groups. For the next six weeks, one group of rats drank water with an amount of fructose that would be roughly equivalent to a person drinking a liter of soda per day. The second group was given fructose water and a diet rich in DHA. The third received water without fructose and no DHA.
After the six weeks, the rats were put through the maze again. The animals that had been given only the fructose navigated the maze about half as fast than the rats that drank only water — indicating that the fructose diet had impaired their memory. The rats that had been given fructose and DHA, however, showed very similar results to those that only drank water — which strongly suggests that the DHA eliminated fructose’s harmful effects.
Other tests on the rats revealed more major differences: The rats receiving a high-fructose diet had much higher blood glucose, triglycerides and insulin levels than the other two groups. Those results are significant because in humans, elevated glucose, triglycerides and insulin are linked to obesity, diabetes and many other diseases.
The research team sequenced more than 20,000 genes in the rats’ brains, and identified more than 700 genes in the hypothalamus (the brain’s major metabolic control center) and more than 200 genes in the hippocampus (which helps regulate learning and memory) that were altered by the fructose. The altered genes they identified, the vast majority of which are comparable to genes in humans, are among those that interact to regulate metabolism, cell communication and inflammation. Among the conditions that can be caused by alterations to those genes are Parkinson’s disease, depression, bipolar disorder, and other brain diseases, said Yang, who also is a member of UCLA’s Institute for Quantitative and Computational Biosciences.
Of the 900 genes they identified, the researchers found that two in particular, called Bgn and Fmod, appear to be among the first genes in the brain that are affected by fructose. Once those genes are altered, they can set off a cascade effect that eventually alters hundreds of others, Yang said.
That could mean that Bgn and Fmod would be potential targets for new drugs to treat diseases that are caused by altered genes in the brain, she added.
The research also uncovered new details about the mechanism fructose uses to disrupt genes. The scientists found that fructose removes or adds a biochemical group to cytosine, one of the four nucleotides that make up DNA. (The others are adenine, thymine and guanine.) This type of modification plays a critical role in turning genes “on” or “off.”
The research is published online in EBioMedicine, a journal published jointly by Cell and The Lancet. It is the first genomics study of all the genes, pathways and gene networks affected by fructose consumption in the regions of the brain that control metabolism and brain function.
Previous research led by Gomez-Pinilla found that fructose damages communication between brain cells and increases toxic molecules in the brain; and that a long-term high-fructose diet diminishes the brain’s ability to learn and remember information.
“Food is like a pharmaceutical compound that affects the brain,” said Gomez-Pinilla. He recommends avoiding sugary soft drinks, cutting down on desserts and generally consuming less sugar and saturated fat.
Although DHA appears to be quite beneficial, Yang said it is not a magic bullet for curing diseases. Additional research will be needed to determine the extent of its ability to reverse damage to human genes.
David Bowie (1947-2016) at Kyoto - Japan - 1980
Photos by Sukita Masayoshi 鋤田 正義
Laplace transform table. Source. (I’m obsessed. <3 And figured y’all would like this one, too!)
Top image via The Roald Dahl Museum and Story Centre
Happy Roald Dahl Day, everyone!
Here’s a selection of some of our favorite stories about the man behind Matilda, Charlie and the Chocolate Factory, The BFG and all the other books that traumatized us so delightfully as kids (Vermicious Knids, eeeeeggghhh).
Roald Dahl Wanted His Magical ‘Matilda’ To Keep Books Alive
Roald Dahl, A Bottle Of Dreams And A 'Letter Of Note’
'Where Am I Now?’ Mara Wilson Explains What Happened When Matilda Grew Up
Roald Dahl: The Story Of The 'Storyteller’
And lest we forget – Dahl’s memoirs and fiction for adults are great too. Just don’t give Someone Like You to a kid.
Wicked And Delicious: Devouring Roald Dahl
– Petra
The Origin of Species by Means of Natural Selection or the Preservation of Favoured Races in the struggle for life Charles Darwin
London John Murray Sixth Edition with additions and corrections (Forty Third Thousand) The sixth edition [shown here] (first printed in 1872) - is the edition in which the word “evolution” was used for the first time (although Darwin used this term in the Descent of Man, published a year before; in 1871). This edition was also the last that Charles Darwin revised during his lifetime, including the addition of an entirely new chapter. In 1876 Darwin added a few small corrections, and all subsequent printing were copies of that printing.
a clean tight fresh presentable copy - which remains largely unread - even after 124 years - a large portion of the book remains unopened [the leaves of the book remain joined at the folds; not slit apart]
(source: http://www.e-keizu.com/info/family.html )
The numbers below match the blue number above in the image.
[M]祖父(そふ sofu), [F]祖母(そぼ sobo)
[M]曾祖父(そうそふ sousofu), [F]曾祖母(そうそぼ sousobo)
[M]高祖父(こうそふ kousofu), [F]高祖母(こうそぼ kousobo)
For big brother/sister of 1, [M]大伯父(おおおじ oooji),[F]大伯母(おおおば oooba) For little brother/sister of 1, [M]大叔父(おおおじ oooji),[F] 大叔母(おおおば oooba)
For big brother/sister of 2, [M]曾祖伯父(そうそはくふ sousohakufu),[F] 曾祖伯母(そうそはくぼ sousohakubo) For little brother/sister of 2, [M]曾祖叔父(そうそしゅくふ sousosyukufu),[F] 曾祖叔母(そうそしゅくぼ sousosyukubo)
For big brother/sister of 3, [M]高祖伯父(こうそはくふ kousohakufu),[F] 高祖伯母(こうそはくぼ kousohakubo) For little brother/sister of 3, [M]高祖叔父(こうそしゅくふ kousosyukufu),[F] 高祖叔母(こうそしゅくぼ kousosyukubo)
For big brother/sister of your father/mother, [M]伯父(おじ oji),[F]伯母(おば oba) For little brother/sister of your father/mother, [M]叔父(おじ oji),[F]叔母(おば oba)
For elder than you, [M]いとこ( itoko )・従兄(じゅうけい juukei),[F]いとこ( itoko )・従姉(じゅうし juushi) For younger than you, [M]いとこ( itoko )・従弟(じゅうてい juutei),[F] いとこ( itoko )・従妹(じゅうまい juumai)
[M]いとこ違い( itokochigai )・従甥(じゅうせい juusei),[F]いとこ違い( itokochigai )・従姪(じゅうてつ juutetsu)
従姪孫(じゅうてっそん juutesson)
For elder than your father/mother, [M]いとこ違い( itokochigai )・従伯父(じゅうはくふ juuhakufu),[F]いとこ違い( itokochigai )・従伯母(じゅうはくぼ juuhakubo ) For younger than your father/mother, [M]いとこ違い( itokochigai )・従叔父(じゅうしゅくふ juushukufu),[F]いとこ違い( itokochigai )・従叔母(じゅうしゅくぼ juushukubo)
For elder than you, [M]またいとこ( mataitoko )・はとこ( hatoko )・再従兄(さいじゅうけい saijuukei),[F]またいとこ( mataitoko )・はとこ( hatoko )・再従姉(さいじゅうし saijuushi) For younger than you, [M]またいとこ( mataitoko )・はとこ( hatoko )・再従弟(さいじゅうてい saijuutei),[F]またいとこ( mataitoko )・はとこ( hatoko )・再従妹(さいじゅうまい saijuumai )
[M]甥(おい oi),[F]姪(めい mei )
[M]姪孫(てっそん tesson)・又甥(またおい mataoi),[F]姪孫(てっそん tesson)・又姪(まためい matamei)
[M/F]曾姪孫(そうてっそん soutesson)
[M/F]玄姪孫(げんてっそん gentesson)
[M/F]孫(まご mago)
[M/F]ひ孫( himago )・曾孫(そうそん souson)
[M/F]やしゃご( yashago )・玄孫(げんそん genson)
[M/F]来孫(らいそん raison)
[M/F]昆孫(こんそん konson)
[M/F]仍孫(じょうそん jouson)
[M/F]雲孫(うんそん unson)
For elder than 1, [M]従祖伯父(じゅうそはくふ juusohakufu )・従大伯父(いとこおおおじ itokooooji ),[F]従祖伯母( じゅうそはくぼ juusohakubo )・従大伯母(いとこおおおば itokooooba) For younger than 1, [M]従祖叔父(じゅうそおじ juusooji)・従大叔父(いとこおおおじ itokooooji),[F]従祖叔母(じゅうそおば juusooba)・従大叔母(いとこおおおば itokooooba)
[M/F]三いとこ(みいとこ miitoko)・その又いとこ(そのまたいとこ sonomataitoko)
Also
You: 自分(じぶん jibun) Mather:母(はは haha) / Father: 父(ちち tsitsi)
(source: http://www.e-keizu.com/info/family.html )
Although I am a Japanese, I can’t call them all correctly… Does your language have the names?
Earlier this semester, I got this book out for a class on the material culture of Christianity. It’s a beautiful Bible bound in purple velvet, with gold embellishments, edges, and clasps. It originally came in a leather case lined with silk, which has since fallen to pieces at the joints, but the same silk features on the gilded endpapers. The clasp is even engraved with the initials of the book’s first owner, Josephine Bonaparte Bolton.
This book is beautiful, but it’s even more interesting after reading the note that came with it from its donor, Josephine’s granddaughter:
When Josephine Bonaparte Bolton was sixteen years old, she taught three negro women to read and write. Her mother, Mrs. Wm. Bolton, was so proud of her daughter’s achievement, that she gave her this little Bible as a memento. The Boltons lived in Jefferson City, Missouri.
Josephine Bolton Kerns (Granddaughter)
June 1, 1977
The clasp is dated 1851, which means that the original Josephine broke Missouri law by giving reading and writing lessons to the three African American women mentioned in the note. Missouri law in 1847 stated that “No person shall keep or teach any school for the instruction of negroes or mulattos, in reading or writing, in this State.” Teaching a person of color to read was punishable by a fine of not less than $500 and up to six months in jail.
I could not find any information about either Josephine, but for the most part, the Bolton families of Cole County and Jefferson City seem to have been Confederate sympathizers. Dr. William Bolton, who may have been Josephine’s father, was a prominent Jefferson City physician and a known slave owner. I’d love to know more about Josephine, her mother, and the story behind this beautiful book. Wouldn’t you?
- Kelli
The Holy Bible, containing the Old and New Testaments : translated out of the original tongues, and with the former translations diligently compared and revised, by His Majesty’s special command, appointed to be read in churches. London : Eyre and Spottiswoode, 1848. Rare BS185 1848 .L6
What the heck is ‘Johnston’s Fluid Beef’? According to this Victorian age flyer in the Canada Medical and Surgical Journal of April 1883, it is “the most perfect food for invalids ever introduced, concentrated preparation for nutritious beef tea or soup, specially recommended by the Medical Faculty.” But the directions for use on page 4 may be a recipe for botulism: “Add a small teaspoon to a cup of boiling water and season to taste; or as a sandwich paste it may be used on toast, with or without butter. The can may remain open for weeks without detriment to the contents.”
The story of ‘Johnston’s Fluid Beef’ began in 1870 in the Franco-Prussian War, when Napoleon III ordered a million cans of beef to feed troops. John Lawson Johnston, a Scot living in Montreal, had the task of providing it. Transportation and storage were problematic, so Johnston created a product known as Johnston’s Fluid Beef, later called Bovril, to meet the need. By 1888, Johnston’s Fluid Beef became a British staple sold in 3,000 U.K. public houses, grocers and dispensing chemists, and remains so today. A major downturn in sales occurred in 2004 when the company changed its formula to make Bovril vegetarian. The Guardian reported in 2007: “Rather than any new-found vegetarian gusto, the move [by Bovril] to yeast extract in 2004 was largely triggered by concerns about beef consumption and BSE [bovine spongiform encephalopathy], which affected Bovril’s export market.” But by 2006, the beef was back in Bovril and the company survives. Modern directions for use are recommended.
David in Singapore, Serious Moonlight Tour 1983
Photo © Denis O’Regan
The U.S. space agency launched a new web-based search engine for much of its catalog of images, video and audio files, which you can browse by keyword and metadata, so that you never have to remember the dismal reality that you’re earthbound ever again.
(Also: Onion Chopping Ninja Reveals Her Timezone!)
It’s Singapore’s National Day today (9th Aug) and I was going to do a Singaporean-based Recipe, (like Hayama’s Curry Fish Head), but didn’t have time to, so here’s a Singapore Food in Manga/Anime Appreciation Post - from Kuragehime, Shokugeki no Souma, and Addicted to Curry!
The Singaporean food that is usually shown in manga/anime is usually either curry-based or chicken rice. And of course, I don’t usually make them at home because: 1. They’re easier to make in bulk 2. You can get them cheaper outside 3. My version would pale in comparison to the masters’ 4. It requires hours of preparation, except for some of the easier curry dishes in Addicted to Curry. (A manga cap of the recipe is above!)
Addicted to Curry lists Singapore as Curry Central, and I never realized how true that was until I went abroad for a couple of years and missed how we would just drown everything in curry, especially for mixed rice dishes like Chap Chye Png and Nasi Briyani. There was also a huge uproar when McDonald’s ran out of Curry Sauce for McNuggets (they have since started selling it in bottles), and a near-riot when a neighbour complained about the smell of another neighbour cooking curry. Also, Gordon Ramsay can’t beat our laksa, even though I think that particular store he challenged isn’t the best one.
(Not everything is curry, of course, but if there’s no curry, generally, there must be chili. And woe betide those who eat the wrong kind of chili with the wrong kind of food. And here’s a PSA for foreigners - Chili Crab is largely for tourists. Take Black Pepper Crab or Salted Egg Crab instead. It’s possible to live as a weak sauce who can’t take spicy foods here, but less exciting. )
Happy 51st Birthday, Singapore! Here’s to the spread of our food all over the world! And a birthday wish would be for more kinds of our food to be shown in manga/anime. :D - O.C.N.
PS: By the way, Eizan Senpai, you can get Hainanese Chicken Rice for $3, and it is considered Street Food even though there are $30+ versions at hotels. Never eaten one with Jidori Chicken, though.
A reblog of nerdy and quirky stuff that pique my interest.
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