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The song “It’s a long way to Tipperary” was enormously popular in New Zealand as a sound recording sung by Stanley Kirkby, with shops advertising new arrivals of stock from overseas in early 1915. At the same time, a film of the same title was also being shown in cinemas, and sheet music for an orchestral arrangement was available at the “Golden Horn” music store in Vivian Street Wellington. Copies of this Maori postcard with its “Tipirere “ translation were handed out to members of the 2nd Maori Contingent of the New Zealand Expeditionary Force after they marched through the streets of Wellington on Saturday 16 September 1915 (See Evening Post, 20 September 1915, page 8).

[Postcard]. Tipirere. N.Z.M.E.C. Hokowhitu-a-Tu. [ca 1915].    

Eph-B-POSTCARD-Vol-12-003-btm

Word of the Day: potlatch

n. An opulent ceremonial feast (among certain North American Indian peoples of the north-west coast) at which possessions are given away or destroyed to display wealth or enhance prestige

Image: “Klallam people at Port Townsend” by James Gilchrist Swan. Public Domain via Wikimedia Commons

The Christopher Robin Story Book from When we were very young, Now we are six, Winnie the Pooh, The House at Pooh Corner by AA Milne Illustrated by Ernest H Shepard London Methuen & Co Ltd. First Edition 1929

(Image caption: Measurement of brain activity in a patient with phantom limb pain. Credit: Osaka University)

Cause of phantom limb pain in amputees, and potential treatment, identified

Researchers have discovered that a ‘reorganisation’ of the wiring of the brain is the underlying cause of phantom limb pain, which occurs in the vast majority of individuals who have had limbs amputated, and a potential method of treating it which uses artificial intelligence techniques.

The researchers, led by a group from Osaka University in Japan in collaboration with the University of Cambridge, used a brain-machine interface to train a group of ten individuals to control a robotic arm with their brains. They found that if a patient tried to control the prosthetic by associating the movement with their missing arm, it increased their pain, but training them to associate the movement of the prosthetic with the unaffected hand decreased their pain.

Their results, reported in the journal Nature Communications, demonstrate that in patients with chronic pain associated with amputation or nerve injury, there are ‘crossed wires’ in the part of the brain associated with sensation and movement, and that by mending that disruption, the pain can be treated. The findings could also be applied to those with other forms of chronic pain, including pain due to arthritis.

Approximately 5,000 amputations are carried out in the UK every year, and those with type 1 or type 2 diabetes are at particular risk of needing an amputation. In most cases, individuals who have had a hand or arm amputated, or who have had severe nerve injuries which result in a loss of sensation in their hand, continue to feel the existence of the affected hand as if it were still there. Between 50 and 80 percent of these patients suffer with chronic pain in the ‘phantom’ hand, known as phantom limb pain.

“Even though the hand is gone, people with phantom limb pain still feel like there’s a hand there – it basically feels painful, like a burning or hypersensitive type of pain, and conventional painkillers are ineffective in treating it,” said study co-author Dr Ben Seymour, a neuroscientist based in Cambridge’s Department of Engineering. “We wanted to see if we could come up with an engineering-based treatment as opposed to a drug-based treatment.”

A popular theory of the cause of phantom limb pain is faulty ‘wiring’ of the sensorimotor cortex, the part of the brain that is responsible for processing sensory inputs and executing movements. In other words, there is a mismatch between a movement and the perception of that movement.

In the study, Seymour and his colleagues, led by Takufumi Yanagisawa from Osaka University, used a brain-machine interface to decode the neural activity of the mental action needed for a patient to move their ‘phantom’ hand, and then converted the decoded phantom hand movement into that of a robotic neuroprosthetic using artificial intelligence techniques.

“We found that the better their affected side of the brain got at using the robotic arm, the worse their pain got,” said Yanagisawa. “The movement part of the brain is working fine, but they are not getting sensory feedback – there’s a discrepancy there.”

The researchers then altered their technique to train the ‘wrong’ side of the brain: for example, a patient who was missing their left arm was trained to move the prosthetic arm by decoding movements associated with their right arm, or vice versa. When they were trained in this counter-intuitive technique, the patients found that their pain significantly decreased. As they learned to control the arm in this way, it takes advantage of the plasticity – the ability of the brain to restructure and learn new things – of the sensorimotor cortex, showing a clear link between plasticity and pain.

Although the results are promising, Seymour warns that the effects are temporary, and require a large, expensive piece of medical equipment to be effective. However, he believes that a treatment based on their technique could be available within five to ten years. “Ideally, we’d like to see something that people could have at home, or that they could incorporate with physio treatments,” he said. “But the results demonstrate that combining AI techniques with new technologies is a promising avenue for treating pain, and an important area for future UK-Japan research collaboration.”

The Blood Of Dragons Could Destroy Antibiotic Resistance

Antibiotic resistance is one of the most pressing problems of our times. Traditional antimicrobial drugs aren’t working the way they used to, and the rise

Antibiotic resistance is one of the most pressing problems of our times. Traditional antimicrobial drugs aren’t working the way they used to, and the rise of “superbugs” could bring about the post-antibiotic age, where easily treatable infections suddenly become life-threatening incurable illnesses.

There have been a slew of new discoveries recently that have revealed brand new ways to turn the tide, but the latest revelation at the hands of a team from George Mason University is a particularly unusual sounding one. As it turns out, we could use the blood of dragons to annihilate superbugs.

No, this isn’t an analogy or a plot line from Game of Thrones. The devil-toothed Komodo dragon – the devious beast from Indonesia – has a particular suite of chemical compounds in its blood that’s pure anathema to a wide range of bacteria.

They’re known as CAMPs – cationic antimicrobial peptides – and although plenty of living creatures (including humans) have versions of these, Komodo dragons have 48, with 47 of them being powerfully antimicrobial. The team managed to cleverly isolate these CAMPs in a laboratory by using electrically-charged hydrogels – strange, aerated substances – to suck them out of the dragons’ blood samples.

Synthesizing their own versions of eight of these CAMPs, they put them up against two strains of lab-grown “superbugs,” MRSA and Pseudomona aeruginosa, to see if they had any effect. Remarkably, all eight were able to kill the latter, whereas seven of them destroyed all trace of both, doing something that plenty of conventional antibiotic drugs couldn’t.

Writing in the Journal of Proteome Research, the researchers write that these powerful CAMPs explain why Komodo dragons are able to contain such a dense, biodiverse population of incredibly dangerous bacteria in their mouths. Although it’s not clear where all these bacteria originally came from, the chemical compounds in their blood ensures that they’ll never be properly infected.

In fact, it was this ability to co-exist with such lethal bacteria that piqued the interest of the researchers in the first place.

“Komodo dragon serum has been demonstrated to have in vitro antibacterial properties,” they note. “The role that CAMPs play in the innate immunity of the Komodo dragon is potentially very informative, and the newly identified Komodo dragon CAMPs may lend themselves to the development of new antimicrobial therapeutics.”

It’ll be awhile before these CAMPs are tested in human trials, but the idea that we’re effectively using dragon’s blood, or plasma, to fight against resurgent diseases is genuinely quite thrilling. Alongside Hulk-like drugs that physically rip bacteria apart, there’s a chance that, with the help of these legendary lizards, we may win this war yet.

The Screwtape Letters C S Lewis London Geoffrey Bles - The Centenary Press 1942 - First Published February 1942, Reprinted March 1942, Reprinted March 1942

dedicated to J R R Tolkien

Can you flatten a sphere?

The answer is NO, you can not. This is why all map projections are innacurate and distorted, requiring some form of compromise between how accurate the angles, distances and areas in a globe are represented.

This is all due to Gauss’s Theorema Egregium, which dictates that you can only bend surfaces without distortion/stretching if you don’t change their Gaussian curvature.

The Gaussian curvature is an intrinsic and important property of a surface. Planes, cylinders and cones all have zero Gaussian curvature, and this is why you can make a tube or a party hat out of a flat piece of paper. A sphere has a positive Gaussian curvature, and a saddle shape has a negative one, so you cannot make those starting out with something flat.

If you like pizza then you are probably intimately familiar with this theorem. That universal trick of bending a pizza slice so it stiffens up is a direct result of the theorem, as the bend forces the other direction to stay flat as to maintain zero Gaussian curvature on the slice. Here’s a Numberphile video explaining it in more detail.

However, there are several ways to approximate a sphere as a collection of shapes you can flatten. For instance, you can project the surface of the sphere onto an icosahedron, a solid with 20 equal triangular faces, giving you what it is called the Dymaxion projection.

The Dymaxion map projection.

The problem with this technique is that you still have a sphere approximated by flat shapes, and not curved ones.

One of the earliest proofs of the surface area of the sphere (4πr2) came from the great Greek mathematician Archimedes. He realized that he could approximate the surface of the sphere arbitrarily close by stacks of truncated cones. The animation below shows this construction.

The great thing about cones is that not only they are curved surfaces, they also have zero curvature! This means we can flatten each of those conical strips onto a flat sheet of paper, which will then be a good approximation of a sphere.

So what does this flattened sphere approximated by conical strips look like? Check the image below.

But this is not the only way to distribute the strips. We could also align them by a corner, like this:

All of this is not exactly new, of course, but I never saw anyone assembling one of these. I wanted to try it out with paper, and that photo above is the result.

It’s really hard to put together and it doesn’t hold itself up too well, but it’s a nice little reminder that math works after all!

Here’s the PDF to print it out, if you want to try it yourself. Send me a picture if you do!

The anime ‘Romeo’s Blue Skies’ is based on a book about a true event which happened in the south of Switzerland unti the 19th century: young boys being sold to Milano to work there as chimney sweepers. There is also a German movie about it called ‘Die Schwarzen Brüder’ [the Black Brothers]. You can watch the trailer here

How many did you know? All worth reading more about!!

11 New Facts Science Has Revealed About The Body

1. Hundreds of genes spring to life after you die - and they keep functioning for up to four days. 

2. Livers grow by almost half during waking hours. 

3. The root cause of eczema has finally been identified.

4. We were wrong - the testes are connected to the immune system after all. 

5. The causes of hair loss and greying are linked, and for the first time, scientists have identified the cells responsible.

6. A brand new human organ has been classified - the mesentery - an organ that’s been hiding in plain sight in our digestive system this whole time.

7. An unexpected new lung function has been found - they also play a key role in blood production, with the ability to produce more than 10 million platelets (tiny blood cells) per hour.

8. Your appendix might actually be serving an important biological function- and one that our species isn’t ready to give up just yet.

9. The brain literally starts eating itself when it doesn’t get enough sleep. brain to clear a huge amount of neurons and synaptic connections away.

10. Neuroscientists have discovered a whole new role for the brain’s cerebellum - it could actually play a key role in shaping human behaviour.

11. Our gut bacteria are messing with us in ways we could never have imagined.  Neurodegenerative diseases like Parkinson’s might actually start out in the gut, rather than the brain, and there’s mounting evidence that the human microbiome could be to blame for chronic fatigue syndrome.

Ojiya chijimi summer kimono, seen on

This type of kimono is made in Niigata prefecture (old Echigo province). Hemp kimono fabric bolt (tanmono) are laid outside to be whitened by sunlight reflecting on the snow. This process is similar to the one used for yuki-tsumugi kimono, and both are registrered as UNESCO Immaterial Heritage.

This process is depicted in Kawabata’s Yukiguni (Snow country)

The chijimi creased effect is considered very chic. Snow-made fabrics are especially appreciated for summer clothings.