Doctor: Looks Like We'll Have To Perform A CAT Scan. Is This Something You're Familiar With?

All the planets as one

Lifelike Illustrations and descriptions of edible Mushrooms. 

By Krombholz, JV,cs . 1831

Contributing Library: Missouri Botanical Garden, Peter H. Raven Library

BioDivLibrary

PUMPKIN-SPICED FLUORESCENCE

Inside a pumpkin, seeds don’t need much chlorophyll—the molecule that helps plants convert light into food—because there isn’t a lot of light deep inside the fruit’s flesh. Instead of chlorophyll, the green seeds are chock-full of protochlorophyllide, a highly fluorescent molecule that glows orange-red under ultraviolet light and can be converted into chlorophyll a by an enzyme in the seeds. The enzyme reduces protochlorophyllide to produce chlorophyll when the enzyme encounters light, which occurs only after the seed has left the pumpkin and therefore needs to start producing its own food so it can grow. Helmut Brandl, a science communicator and professor at ETH Zurich, extracted this protochlorophyllide by grinding up pumpkin seeds and mixing them with nail polish remover (bottom row).

Submitted by Helmut Brandl

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Look Deep Inside

never don't reblog labphoto

Distillation of the reaction product from a pressure tube. 

This picture may look like that’s nothing special with it, but in the receiving flask (left side) there is a really-really special disulfide what I was able to prepare first time in pure form with a high yield. For months I was unable to prepare this molecule with a high selectivity from the starting materials. Always at least 2-5 side products formed and the product was only isolated in a low, 10-20% yield. 

Reverse psychology that's not in psychology. Reverse biology...?

How did you decide to do a project with RNA?

I was having a conversation with someone in our department about how useful and cheap next-gen sequencing is, and how I was considering spending out my grant on a project looking at immune gene expression in spiders. He told me flat out that I wasn’t capable of doing it, because I wouldn’t understand it enough to ever publish. So I used a kit to extract RNA, sent off the samples, read a few books in the meantime, learned to code, wrote the scripts for R and the supercomputer, then did it. I’m writing it up now, and have found some pretty cool stuff! I’m glad I learned it too, since it’s a good skill to have.

TL;DR: some asshole told me I couldn’t do it, so I decided to do it.

We were just discussing in class today in the context of ubiquinated H2B. Neat!

Ubiquitin is a regulatory protein found in most tissues of many walled-celled organisms.  Originally known as  ubiquitous immunopoietic polypeptide, ubiquitin was discovered in 1975 and its mechanism identified by a team including  Aaron Ciechanover, Avram Hershko, and Irwin Rose of the Fox Chase Cancer Center, for which they were awarded the Nobel Prize in Medicine in 2004.  Ubiquitins act as traffic control agents within the cell, directing other proteins to various compartments within the cell including tagging proteins for destruction.  

The word ubiquitin was formed in 1975 from the English adjective ubiquitous which dates only from 1837.  Ubiquitous derives from the noun ubiquitary which dates from 1580s from the Latin preposition ubi meaning where and que meaning any, also, ever.  Ubiquitary (meaning everywhere) originally referred to the Luthern doctrine that Christ is omnipresent.  

Representation of ubiquitin protein, highlighting the secondary structure. α-helices are coloured in blue and β-strands in green. The sidechains of the 7 lysine residues are indicated by orange sticks. The two best-characterised attachment points for further ubiquitin molecules in polyubiquitin chain formation (lysines 48 & 63) are labelled.

Image of ubiquitin protein courtesy rogerdodd under a Creative Commons 3.0 license, used with permission.

Lovely crystallization effect from an extraction the other day

Two jets colliding can form a chain-like fluid structure. With increasing flow rate, the rim of the chains becomes wavy and unstable, forming a fishbone structure where droplets extend outward from the fluid sheet via tiny ligaments. Eventually, the droplets break off in a pattern as beautiful as it is consistent. (Photo credits: A. Hasha and J. Bush)