Scientists Print All-liquid 3-D Structures

Gene discovery unlocks mysteries to our immunity

"It's exciting to consider that C6 has existed for more than 500 million years, preserved and passed down from simple organisms all the way to humans. But only now are we gaining insights into its importance."

Australia’s national science agency CSIRO has identified a new gene that plays a critical role in regulating the body’s immune response to infection and disease.

The discovery could lead to the development of new treatments for influenza, arthritis and even cancer.

The gene, called C6orf106 or “C6”, controls the production of proteins involved in infectious diseases, cancer and diabetes. The gene has existed for 500 million years, but its potential is only now understood.

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Spikes of graphene can kill bacteria on implants

A tiny layer of graphene flakes becomes a deadly weapon and kills bacteria, stopping infections during procedures such as implant surgery

A tiny layer of graphene flakes becomes a deadly weapon and kills bacteria, stopping infections during procedures such as implant surgery. This is the findings of new research from Chalmers University of Technology, Sweden, recently published in the scientific journal Advanced Materials Interfaces.

Operations for surgical implants, such as hip and knee replacements or dental implants, have increased in recent years. However, in such procedures, there is always a risk of bacterial infection. In the worst case scenario, this can cause the implant to not attach to the skeleton, meaning it must be removed.

Bacteria travel around in fluids, such as blood, looking for a surface to cling on to. Once in place, they start to grow and propagate, forming a protective layer, known as a biofilm.

A research team at Chalmers has now shown that a layer of vertical graphene flakes forms a protective surface that makes it impossible for bacteria to attach. Instead, bacteria are sliced apart by the sharp graphene flakes and killed. Coating implants with a layer of graphene flakes can therefore help protect the patient against infection, eliminate the need for antibiotic treatment, and reduce the risk of implant rejection. The osseointegration – the process by which the bone structure grow to attach the implant – is not disturbed. In fact, the graphene has been shown to benefit the bone cells.

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Biggest Ferris wheel ever: the Jupiter Eye

NASA just released Juno’s brand-new images of Jupiter’s red spot — and they’re jaw-dropping

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Smart ink adds new dimensions to 3-D printing

Researchers at Dartmouth College have developed a smart ink that turns 3D-printed structures into objects that can change shape and color. The innovation promises to add even more functionality to 3D printing and could pave the way to a new generation of printed material.

The advancement in the area of form-changing intelligent printing - also known as 4D printing - provides a low-cost alternative to printing precision parts for uses in areas ranging from biomedicine to the energy industry.

“This technique gives life to 3D-printed objects,” said Chenfeng Ke, an assistant professor of chemistry at Dartmouth. “While many 3D-printed structures are just shapes that don’t reflect the molecular properties of the material, these inks bring functional molecules to the 3D printing world. We can now print smart objects for a variety of uses.”

Many 3D printing protocols rely on photo-curing resins and result in hard plastic objects with rigid, but random molecular architectures. The new process allows designers to retain specific molecular alignments and functions in a material and converts those structures for use in 3D printing.

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The perfect news in EVERY WAY.

I have nothing to do with this mission, but damn do I feel proud. What peculiar beings we, humans, are. Sending into space a doll in a spacesuit, named “Starman”, seated in an electric car, with a sign “Don’t Panic” on the car’s dashboard, blasting David Bowie’s “Life On Mars?”. I’m not crying, you are.

CRISP(ie)R news than anything!

Enzyme tweak boosts precision of CRISPR genome edits

Engineered enzyme drives genome-editing errors below detection limit.

A powerful technique for editing genomes is now more precise. By tweaking an enzyme, researchers have reduced the error rate for the technique, known as CRISPR–Cas9 — in some cases to undetectable levels, they report on 6 January in Nature1.

Researchers use CRISPR–Cas9 to make precise changes to genomes that remove or edit a faulty gene. It has worked on nearly every creature on which they have tested it, including human embryos.

The technique relies on an enzyme called Cas9, that uses a ‘guide RNA’ molecule to home in on its target DNA. Cas9 cuts the DNA at that site, and the cell’s natural DNA repair machinery then takes over to mend the cut — deleting a short fragment of DNA or stitching in a new sequence in the process.

But the technology is not infallible: sometimes the Cas9 enzyme creates unwanted mutations. As CRISPR inches out of the laboratory and towards the clinic — with debates raging overwhether it should be deployed in embryos — researchers have pushed to reduce the error rate.

The latest study moves the field closer to that goal, says lead author Keith Joung, a pathologist at Massachusetts General Hospital in Boston. “This is a significant move forward,” he says. “We can very much reduce the probability of off-targets.”

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NASA blasts off Mars lander, InSight

Vandenberg AFB CA (AFP) May 05, 2018 NASA on Saturday blasted off its latest Mars lander, InSight, designed to perch on the surface and listen for “Marsquakes” ahead of eventual human missions to explore the Red Planet. “Three, two, one, liftoff!” said a NASA commentator as the spacecraft launched on a dark, foggy morning atop an Atlas V rocket at 4:05 am Pacific time (1105 GMT) from Vandenberg Air Force Base in California, m Full article

"Who is afraid of Super Woolf?"

Sound metal, don't you think?

Engineers 3-D print high-strength aluminum, solve ages-old welding problem using nanoparticles

HRL Laboratories has made a breakthrough in metallurgy with the announcement that researchers at the famous facility have developed a technique for successfully 3D printing high-strength aluminum alloys—including types Al7075 and Al6061—that opens the door to additive manufacturing of engineering-relevant alloys. These alloys are very desirable for aircraft and automobile parts and have been among thousands that were not amenable to additive manufacturing—3D printing—a difficulty that has been solved by the HRL researchers. An added benefit is that their method can be applied to additional alloy families such as high-strength steels and nickel-based superalloys difficult to process currently in additive manufacturing.

“We’re using a 70-year-old nucleation theory to solve a 100-year-old problem with a 21st century machine,” said Hunter Martin, who co-led the team with Brennan Yahata. Both are engineers in the HRL’s Sensors and Materials Laboratory and PhD students at University of California, Santa Barbara studying with Professor Tresa Pollock, a co-author on the study. Their paper 3D printing of high-strength aluminum alloys was published in the September 21, 2017 issue of Nature.

Additive manufacturing of metals typically begins with alloy powders that are applied in thin layers and heated with a laser or other direct heat source to melt and solidify the layers. Normally, if high-strength unweldable aluminum alloys such as Al7075 or AL6061 are used, the resulting parts suffer severe hot cracking—a condition that renders a metal part able to be pulled apart like a flaky biscuit.

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