Antimicrobial Agents - Inhibition Of DNA And Protein Synthesis

are you a pink lemonade gay or a vanilla coke gay? sword gay or axe gay? cats and dogs gay or snakes and lizards gay? string lights gay or neon lights gay?

guys… I don’t know if you know this but… if you wake up early… there’s so many more hours in the day

Lmao what did Ariana do that means she needs to get booed at Manchester?

google is free and this article does a good job of explaining but because i dont want anyone to continue to give this girl money for being shit person, here we go.

besides being a cishet white woman HEADING a PRIDE EVENT (Which is something i shouldnt need to explain why its bad.. pride is by and for lgbt people and should not be HEADLINING a cishet.) 

Racism

this is her like 5 years ago vs her now. she is a white girl wearing blackface.  and before you go “thats not blackface! thats just a tan!!!” 

this is her on stage next to nicki minaj, a black woman. she is darker than nicki minaj. this is what a tan looks like

a tan is supposed to give you a more golden sun touched look, NOT MAKE YOU LOOK LIKE A DIFFERENT RACE! (also tan is a golden/yellow brown, not a deep brown… this is not an accident)

her hair, by the way, is in fact exensions. again, making her hair thicker and darker in order to pass as a poc… she steals from black musicians too… like its not news that white people steal culture from poc then market it as a new trend but… she really takes it to a whole new level and acts as if her new look is some fucking brand she made. 

remember shen she got a tattoo for 7 rings but didnt finish it and said “oh thats just fine :)” ? 

transmisogyny

in her video “thank you next” she has a man in a dress stereotype for a trans girl, then painted said person as desperate for a date.  this is a transmisogynist caracature. she is a cishet girl. this is transphobic. end of discussion.

homophobia

shouldnt have to explain why a het girl using sexualized lesbians that look like they came out of a porno for men in a music video for views isnt ok.

etc

she ignores when everyone first tried to tell her NICELY that what she was doing is wrong but as soon as people got less than kind about it, got all guilt trippy like a 3 yr old and went “why cant we just all get along its so sd to see people hating like this :(((((( be nice :(( “ 

she is friends with Pierce Morgan (known facist) and is QUITE PUBLIC ABOUT THIS, she constantly preaches the “we should just sit down and talk to people who are flaming bigots. their bigotry is just a difference of opinions ❤️❤️❤️” which is propaganda created by, surprise, the very bigots it refers to. if we dont fight or get upset then they can continue to be horrible people without consequence. 

she is now INSISTING on headlining pride, and i have seen more homophobic people than i can count say theyre going to buy tickets to pride just to see her. let me repeat that. homophobes are going to pride to see a homophobic artist. this is disgusting. this puts every gay and trans person there in danger. actually, it puts everyone there in danger because it is a pride event and any homophobes will see you there and assume youre gay anyhow so! 

tldr: ariana grande is a racist, transphobic, homophobic white girl parading around in blackface and appropriates black, latino, and asian cultures for $$$ and uses lgbt people for views.

Pregnancy - physiology

Hormones

hCG - human chorionic gonadotropin - present in blood and urine, produced by blastocyst and placenta

Low levels of hCG could mean miscarriage, ectopic pregnancy, miscalculation of dates

High levels = molar pregnancy (cells that normally form a baby dysfunction and form cysts instead), multiple pregnancy (twins etc), miscalculation of dates

Progesterone increases fat deposition in early weeks and stimulates appetite

Increased oestrogen from corpus luteum promotes mammary gland development (breasts enlarge)

And inhibits ovulation via negative feedback [OES decreases GnRH release by hypothalamus –> linhibition of FHS and LH –> no ovulation]

Relaxin (secreted by corpus luteum) softens connective tissue in preparation for labour - not specific, all joints can be affected

Peaks in early and late pregnancy

Physical changes

Blood pressure

As early as 4 weeks into pregnancy 

plasma volume increase

caused by the affects of oestrogen and progesterone on the kidneys

OES and Prg cause vasodilation 

less resistance = less pressure

Heart rate increases by 25% to compensate

stroke volume increases 

increased overall cardiac output by 50% in third trimester

Direct action of enlarged uterus:

compresses the descending aorta and inferior vena cava 

decreased venous return - less blood in means less blood out, less blood in ventricle –> reduced pressure on walls –> reduced force to exit –> reduced placental perfusion

increased aortic pressure

increased heart rate

[shouldn’t sleep on back for this reason]

Outcomes:

Fall in blood pressure (can cause collapse if serious)

Can cause foetal hypoxia even without mother symptoms

Haematological changes

red cell mass increase by 20% (renal - increased erythropoietin production in response to detection of blood oxygenation and sodium/water balance)

Plasma volume increases more than RBC count does, causing the impression of decreased haemoglobin (anaemia)

Increased tendency to clot (hypercoagulable)

due to increase in clotting factors and plasma fibrinogen

platelet production increase (however count drops due to increase in activity and consumption) - function remains normal]

WBC count may increase due to an increase in granulocytes

Respiratory changes

Increased chest diameter, diaphragmatic expression and elevation

dyspnoea common (difficulty breathing)

breathing becomes more costal (mouth) than abdominal 

mainly mediated by progesterone levels (cause bronchial and smooth muscle relaxation and hypersensitivity to CO2)

Changes to the urinary system

cardiac output increase –> increase in renal plasma flow and glomerular filtration

increase in urea, creatinine, urate and biocarbonate clearance 

with progesterone, renin and aldosterone up water retention increases

can lead to urinary stasis and increased risk of UTI

Any drugs given that are excreted renally must be given in much higher quantities consequently

Gastrointestinal changes

Appetite increase + cravings 

Gastric reflux sphincter relaxation (increased indigestion, also due to increased intra-gastric pressure (expanding uterus)) 

gallbladder dilated 

GI motility decreased and transit time slower 

albumin and protein decrease 

cholesterol twice normal value

Muskuloskeletal 

Calcium reuptake into bloodstream results in mild decalcification of bones 

relaxin softens joints (pubic symphysis + alters gait (waddling))

abdominal muscles stretch to elastic limit 

stretch marks (stria gravidarum) caused by rupture of elastic fibres and small blood vessels 

Reproductive changes

Massive increase in mass

Placenta growth (nutrition, excretion, immunity, endocrine) 

Parental blood supply 

Mind blown 😂

Me, thinking about high school:

Iconic Bellarke lines

To get you through these tough times, until Bellarke is an official ship.

1. Bellamy: If I’m on that list, you’re on that list. Write it down or I will.

2. Bellamy: Clarke, If I don’t see you again-

Clarke: No, You will

3. Bellamy: We can’t lose Clarke! We can’t lose her.

4. Clarke: You’ve got such a big heart Bellamy. People follow you, you inspire them because of this (Touches his heart). But the only way we’re gonna get through this is if you use this too (touches his head).

Bellamy: I got you for that.

5. Clarke: The Heart and the Head.

Bellamy: The Heart and the head

6. Bellamy: I was so mad at you for leaving. I don’t want to feel that way anymore.

7. Bellamy: Besides, I could use a break from keeping you alive.

Clarke: Thank you for keeping me alive.

Bellamy: Well, you don’t make it easy.

8. Diyoza: 283 lives for one. She must be pretty important to you.

Bellamy: She is.

9. Jaha: She’s lucky to have you. You keep her centred.

Bellamy: You got it backwards.

10. Bellamy: Together.

Forgot I made these quick refs once!! It’s not that you should feel obligated to portray every part of an animal correctly, but in some cases these are very unique, interesting features that very few artists are ever utilizing creatively!

tag yourself: note takers edition

Takes digital notes: tries to keep up with notetaking but eventually falls behind after 5 lectures, drinks coffee only to stay awake, tries the aesthetic of drinking hot tea while taking notes but fails, wakes up early once in a century and thinks they’ve reached their peak, wants a better organisation system but is too tired, worries about studyspo for 2 mins before saying fuck it

Takes handwritten notes: have really nice handwriting but they don’t realise it themselves, headers!! are!! everything!!, have a love-hate relationship with taking notes, studying only when they feel like it, only writes key points as notes because everything else is too much, drifts off a lot while notetaking to daydream

Doesn’t take notes: wears hoodies like 90% of the time, tries really hard to take care of themselves but it’s hard™, hair in a bun because hairstyles?? too much work, yells “fuck the system” as they study more than anyone else, studies straight from books and Knows what to study, can’t study for more than 45 mins at a time, is productive nonetheless, kinda exhausted but still carrying on

Takes notes only in class: take! notes! in! class! save! your! time! fuckers!, in a constant state of chaos but they’ll never admit, have a great relationship with the professors, raises eyebrows at everything it’s a Brand, likes lunch dates a lot, hates people who talk during lectures, wants a vacation already

Is still rotating between handwriting and typed notes: “did we have any homework” at the beginning of every lecture, is really friendly but tired of everything, likes laughing at stupid jokes, hates studying but is still doing it anyway, Major Chaos™, everyone loves them but they don’t have a lot of close friends, will fight for their friends to death, the mood: they’re just being their ball of anxiety, let them live thnx

so I got into grad school today with my shitty 2.8 gpa and the moral of the story is reblog those good luck posts for the love of god